Dehydroepiandrosterone Supplementation May Benefit Women with Asthma Who Have Low Androgen Levels: A Pilot Study.

Journal: Pulmonary therapy
Published Date: Oct 21, 2019

Abstract

INTRODUCTION: Among individuals with severe asthma, FEV is low in individuals with low dehydroepiandrosterone (DHEA) sulfate (DHEAS) levels. In the Severe Asthma Research Program (SARP), no women with DHEAS > 200 μg/dL had an FEV < 60% predicted. DHEA has benefited patients with COPD and pulmonary hypertension in small trials. Therefore, we hypothesized that DHEA supplementation may improve FEV in asthmatic women with low DHEAS.

Authors

  • Nadzeya Marozkina
    Case Western Reserve University, Cleveland, OH, USA.
  • Joe Zein
    Case Western Reserve University, Cleveland, OH, USA.
  • Mark D DeBoer
    University of Virginia, Charlottesville, VA, USA.
  • Laurie Logan
    Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
  • Laura Veri
    Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
  • Kristie Ross
    Case Western Reserve University, Cleveland, OH, USA.
  • Benjamin Gaston
    Case Western Reserve University, Cleveland, OH, USA. begaston@iu.edu.

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