Pharmacokinetics and Pharmacodynamics of Anti-infective Agents during Continuous Veno-venous Hemofiltration in Critically Ill Patients: Lessons Learned from an Ancillary Study of the IVOIRE Trial.

Journal: Journal of translational internal medicine
Published Date: Dec 31, 2019

Abstract

BACKGROUND: Hemofiltration rate, changes in blood and ultrafiltration flow, and discrepancies between the prescribed and administered doses strongly influence pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents during continuous veno-venous hemofiltration (CVVH) in critically ill patients.

Authors

  • Dominique Breilh
    Laboratory of Clinical Pharmacokinetics and Clinical Pharmacy, INSERM U1034, Haut-Lévêque Hospital, CHU Bordeaux, University of Bordeaux, Segalen, Pessac, France.
  • Patrick M Honore
    Intensive Care Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Brussels, Belgium.
  • David De Bels
    Intensive Care Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Brussels, Belgium.
  • Jason A Roberts
    Centre for Translational Anti-infective Pharmacodynamics, Pharmacy Australia Centre of Excellence, Brisbane, Queensland, Australia.
  • Jean Baptiste Gordien
    Laboratory of Clinical Pharmacokinetics and Clinical Pharmacy, INSERM U1034, Haut-Lévêque Hospital, CHU Bordeaux, University of Bordeaux, Segalen, Pessac, France.
  • Catherine Fleureau
    CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan Medico-Surgical Centre, F-33000 Bordeaux, France.
  • Antoine Dewitte
    CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan Medico-Surgical Centre, F-33000 Bordeaux, France.
  • Julien Coquin
    CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan Medico-Surgical Centre, F-33000 Bordeaux, France.
  • Hadrien Rozé
    CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan Medico-Surgical Centre, F-33000 Bordeaux, France.
  • Paul Perez
    Centre Hospitalier Universitaire de Bordeaux, Pôle de Santé Publique, Unité de Soutien Méthodologique à la Recherche Clinique et Épidémiologique, France.
  • Rachid Attou
    Intensive Care Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Brussels, Belgium.
  • Sebastien Redant
    Intensive Care Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Brussels, Belgium.
  • Luc Kugener
    Intensive Care Department, Centre Hospitalier Universitaire Brugmann-Brugmann University Hospital, Brussels, Belgium.
  • Marie-Claude Saux
    Laboratory of Clinical Pharmacokinetics and Clinical Pharmacy, INSERM U1034, Haut-Lévêque Hospital, CHU Bordeaux, University of Bordeaux, Segalen, Pessac, France.
  • Herbert D Spapen
    Ageing & Pathology Research Group, Vrije Universiteit Brussel, Brussels, Belgium.
  • Alexandre Ouattara
    CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan Medico-Surgical Centre, F-33000 Bordeaux, France.
  • Olivier Joannes-Boyau
    CHU Bordeaux, Department of Anaesthesia and Critical Care, Magellan Medico-Surgical Centre, F-33000 Bordeaux, France.

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