Differentiation of non-small cell lung cancer and histoplasmosis pulmonary nodules: insights from radiomics model performance compared with clinician observers.

Journal: Translational lung cancer research
Published Date: Dec 1, 2019

Abstract

BACKGROUND: Histoplasmosis pulmonary nodules often present in computed tomography (CT) imaging with characteristics suspicious for lung cancer. This presents a work-up decision issue for clinicians in regions where histoplasmosis is an endemic fungal infection, when a nodule suspicious for lung cancer is detected. We hypothesize the application of radiomic features extracted from pulmonary nodules and perinodular parenchyma could accurately distinguish between suspicious histoplasmosis lung nodules and non-small cell lung cancer (NSCLC).

Authors

  • Johanna Uthoff
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
  • Prashant Nagpal
    Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
  • Rolando Sanchez
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
  • Thomas J Gross
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
  • Changhyun Lee
    Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
  • Jessica C Sieren
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals