Choline Carboxylic Acid Ionic Liquid-stabilized Anisotropic Gold Nanoparticles for Photothermal Therapy.

Journal: ACS applied nano materials
Published Date: Jan 29, 2024

Abstract

Gold nanoparticles (AuNPs) are commonly used in cancer research due to their unique physical and optical properties. However, current AuNP synthesis methods often involve cytotoxic cationic surfactants like cetyltrimethyl ammonium bromide (CTAB). Tedious CTAB replacement methodologies have been used to increase the biocompatibility, further increasing the complexity of synthesizing biocompatible AuNPs limiting their biomedical applications. To address this issue, we explore cholinium decanoate (CADA) ionic liquid (IL) as a biocompatible stabilizing agent by replacing CTAB using a simple modified seeded method for synthesizing anisotropic AuNPs for photothermal therapy of triple-negative breast cancer cells (MDA-MB-231). The prepared CADA AuNPs showed quasi-spherical morphology, confirmed by transmission electron microscopy (TEM) and a broad plasmonic absorption band using Vis-NIR spectroscopy. CADA AuNPs exhibited excellent in-vitro biocompatibility with both MCF-10A (healthy human mammary cells) and MDA-MB-231 cells. We evaluate their in-vitro photothermal efficacy against MDA-MB-231 cancer cells, demonstrating significant cell death even at low AuNP concentration (20 μg/mL), low laser power density (0.6 W/cm, 808 nm continuous laser), and short irradiation time of 5 minutes, primarily through apoptosis. Overall, this work represents the first effort in using a modified seeded method for synthesizing biocompatible IL-based anisotropic AuNPs for photothermal therapy, offering a promising avenue for future cancer treatment research using ILs.

Authors

  • Priyavrat Vashisth
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Cameron L Smith
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Dhanush L Amarasekara
    Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
  • Gaya S Dasanyake
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Gagandeep Singh
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Claylee M Chism
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Christine M Hamadani
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Tanveer Shaikh
    Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
  • Noah Grovich
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Briana Gamboa
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Nicholas C Fitzkee
    Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
  • Nathan I Hammer
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.
  • Eden E L Tanner
    Department of Chemistry & Biochemistry, The University of Mississippi, University, MS 38677, United States.

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