Bioactivity of semisynthetic eugenol derivatives against (Lepidoptera: Noctuidae) larvae infesting maize in Colombia.
Journal:
Saudi journal of biological sciences
Published Date:
Sep 27, 2018
Abstract
The anti-acetylcholinesterase, larvicidal, antifeedant activities and general toxicity of 15 semisynthetic eugenol derivatives based on clove oil (including the own oil), were evaluated against the maize armyworm, (J.E. Smith). Therefore, promising eugenol molecules were classified with larvicidal, anti-acetylcholinesterase and antifeedant activities for controlling this pest. During structure-activity relationship studies and physicochemical profile analysis, it was found that among tested molecules -, eugenol , prenyl eugenol , isoeugenol and isoeugenol acetate exhibited lethal effects LD at concentrations <1 mg/g of insect. On the other hand, eugenol , metallyl eugenol , isoeugenol and isoeugenol acetate showed a good antifeedant activity (CE = 158-209 µg/mL) with a high antifeedant index (70-78%) at concentration 1000 µg/mL, possessing a weak anti-acetylcholinesterase activity (IC = 21-31 μg/mL). According to their ecotoxicological profiles (LC = 2033.1-6303.8 µg/mL on larvae), isoeugenol and its acetate derivative could be potential used in control of the growth, feeding, or reproduction of larvae, acting as moderate insecticidal acetylcholinesterase inhibitors and/or antifeedant molecules. Such structure-activity relationship studies could stimulate the identification of lead structures from natural sources for the development of larvicidal and deterrent products against and related insect pests.
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