ShapeShifter: a novel approach for identifying and quantifying stable lariat intronic species in RNAseq data.
Journal:
Quantitative biology (Beijing, China)
Published Date:
Jul 25, 2018
Abstract
BACKGROUND: Most intronic lariats are rapidly turned over after splicing. However, new research suggests that some introns may have additional post-splicing functions. Current bioinformatics methods used to identify lariats require a sequencing read that traverses the lariat branchpoint. This method provides precise branchpoint sequence and position information, but is limited in its ability to quantify abundance of stabilized lariat species in a given RNAseq sample. Bioinformatic tools are needed to better address these emerging biological questions.
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