Ascending Lipopolysaccharide-Induced Intrauterine Inflammation in Near-Term Rabbits Leading to Newborn Neurobehavioral Deficits.

Journal: Developmental neuroscience
Published Date: Jun 4, 2019

Abstract

BACKGROUND: Chorioamnionitis from ascending bacterial infection through the endocervix is a potential risk factor for cerebral palsy. Tetrahydrobiopterin, an essential cofactor for nitric oxide synthase (NOS) and amino acid hydroxylases, when augmented in the fetal brain, prevents some of the cerebral palsy-like deficits in a rabbit hypoxia-ischemia model.

Authors

  • Zhongjie Shi
    Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan, USA, tua64317@gmail.com.
  • Jeannette Vasquez-Vivar
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Kehuan Luo
    Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan, USA.
  • Yan Yan
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, USA.
  • Frances Northington
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Mohammad Mehrmohammadi
    Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, USA.
  • Sidhartha Tan
    Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan, USA.

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