Investigations into the physical and chemical stability of concentrated co-trimoxazole intravenous infusions.

Journal: European journal of hospital pharmacy : science and practice
Published Date: Jul 19, 2017

Abstract

OBJECTIVES: High dose of intravenous sulfamethoxazole and trimethoprim (co-trimoxazole) is often used in immunocompromised patients for the treatment of pneumonia. Current manufacturer's dilution recommendation for intravenous co-trimoxazole (1:25 v/v) requires the administration of 2 L of additional fluid per day causing serious complications including pulmonary oedema. Intravenous administration of concentrated solution of co-trimoxazole may minimise the risk of fluid overload associated side effects. Therefore, the objective of the study was to investigate the physicochemical stability of concentrated intravenous co-trimoxazole solutions.

Authors

  • Israa Khaleel
    School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
  • Syed Tabish R Zaidi
    Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia.
  • Madhur D Shastri
    School of Health Sciences, University of Tasmania, Hobart, Tasmania, Australia.
  • Mathew Suji Eapen
    School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
  • Long Chiau Ming
    Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia.
  • Troy Wanandy
    Department of Pharmacy, Royal Hobart Hospital, Hobart, Australia.
  • Rahul P Patel
    Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia.

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