Physicochemical stability of voriconazole in elastomeric devices.

Journal: European journal of hospital pharmacy : science and practice
Published Date: Apr 10, 2017

Abstract

OBJECTIVES: Voriconazole is the drug of choice for invasive aspergillosis (IA), a leading cause of mortality and morbidity in immunocompromised patients. Prolong intravenous administration of voriconazole is often needed in such patients due to high incidence of oral mucositis and unreliable bioavailability of oral dosage form. Administration of voriconazole through elastomeric pump may facilitate early hospital discharge of clinically stable immunocompromised patients needing prolonged intravenous treatment. Therefore, we investigated the physicochemical stability of voriconazole in one of the commonly used elastomeric pumps at three different temperatures for various time points.

Authors

  • Harmanjeet Harmanjeet
    Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
  • Syed Tabish R Zaidi
    Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia.
  • Long Chiau Ming
    Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia.
  • Troy Wanandy
    Department of Pharmacy, Royal Hobart Hospital, Hobart, Australia.
  • Rahul P Patel
    Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Australia.

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