Chemical and microbiological stability, anticoagulant efficacy and toxicity of 35 and 90 mM trisodium citrate solutions stored in plastic syringes.

Journal: European journal of hospital pharmacy : science and practice
Published Date: Jan 13, 2017

Abstract

BACKGROUND: Trisodium citrate is an interesting alternative to heparin for the prevention of circuit clotting during extracorporeal procedures, but some protocols require non-commercially available citrate concentrations. Little published information is available about the stability of diluted citrate solutions.

Authors

  • Paola Milla
    Department of Drug Science and Technology, University of Turin, Turin, Italy.
  • Maria Luisa Viterbo
    Hospital Pharmacy, San Giovanni Bosco Hospital, Turin, Italy.
  • Sabino Mosca
    Department of Anesthesiology and Resuscitation, San Giovanni Bosco Hospital, Turin, Italy.
  • Silvia Arpicco
    Department of Drug Science and Technology, University of Turin, Turin, Italy.

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