Compatibility of proton pump inhibitors in a preservative-free suspending vehicle.

Journal: European journal of hospital pharmacy : science and practice
Published Date: Nov 25, 2016

Abstract

OBJECTIVES: To evaluate the microbiological and physicochemical compatibility of commonly used proton pump inhibitors (PPIs) esomeprazole, lansoprazole, omeprazole and pantoprazole compounded at a single concentration using SyrSpend SF Alka and stored at refrigerated temperatures (omeprazole was also stored at room temperature because it has the most widespread use).

Authors

  • Hudson C Polonini
    Ortofarma-Quality Control Laboratories, Matias Barbosa, MG, Brazil.
  • Sharlene L Silva
    Ortofarma-Quality Control Laboratories, Matias Barbosa, MG, Brazil.
  • Shirley Loures
    Ortofarma-Quality Control Laboratories, Matias Barbosa, MG, Brazil.
  • Rachel Almy
    Eurofins-Pharma Quality Control, Sainte Croix en Plaine, France.
  • Antoine Balland
    Eurofins-Pharma Quality Control, Sainte Croix en Plaine, France.
  • Marcos Antônio F Brandão
    Ortofarma-Quality Control Laboratories, Matias Barbosa, MG, Brazil.
  • Anderson O Ferreira
    Ortofarma-Quality Control Laboratories, Matias Barbosa, MG, Brazil.

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