Furosemide ethanol-free oral solutions for paediatric use: formulation, HPLC method and stability study.

Journal: European journal of hospital pharmacy : science and practice
Published Date: Aug 2, 2017

Abstract

BACKGROUND: Oral liquid solutions of the diuretic active ingredient furosemide (FUR) marketed across Europe do not comply with recent requirements for paediatric preparation owing to their ethanol content and, moreover, in some countries only tablet or injection dosage forms of furosemide are available.

Authors

  • Lukáš Zahálka
    Department of Analytical Chemistry, Charles University, Hradec Kralove, Czech Republic.
  • Sylva Klovrzová
    Department of Pharmaceutical Technology, Charles University, Hradec Kralove, Czech Republic.
  • Ludmila Matysová
    Department of Analytical Chemistry, Charles University, Hradec Kralove, Czech Republic.
  • Zdenka Šklubalová
    Department of Pharmaceutical Technology, Charles University, Hradec Kralove, Czech Republic.
  • Petr Solich
    Department of Analytical Chemistry, Charles University, Hradec Kralove, Czech Republic.

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