Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis.

Journal: Frontiers in pharmacology
Published Date: Jan 24, 2025

Abstract

INTRODUCTION: Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition with no specific treatment. Inhibiting osteocyte apoptosis may be a promising therapeutic approach. Shengxue Busui Decoction (SBD) has shown protective effects against SONFH, but its mechanisms are not fully understood. This study aims to investigate the effects of SBD on SONFH in rats, identifying its key active components and regulatory mechanisms using network pharmacology, bioinformatics, machine learning, and experimental validation.

Authors

  • Manting Liu
    Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Jiexiang Ye
    The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan, China.
  • Runtian Wu
    Guangzhou Hospital of Integrated Traditional and Western Medicine Affiliated to Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Dongqiang Luo
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Tao Huang
    The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Dandan Dai
    The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Kexin Wang
    Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Yanping Du
    Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Junwen Ou
    Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals