Updated NACI recommendations for measles post-exposure prophylaxis.

Journal: Canada communicable disease report = Releve des maladies transmissibles au Canada
Published Date: Sep 6, 2018

Abstract

BACKGROUND: Human immune globulin (Ig) products are currently recommended as post-exposure prophylaxis (PEP) for measles in certain susceptible groups. However, successful measles vaccination programs in North America have led to low circulation of measles virus and most blood donors now have vaccine-derived immunity. Concurrently, the concentrations of anti-measles antibodies in human Ig products have shown trends of gradual decline and previously recommended doses and routes of administration may no longer be optimally protective.

Authors

  • M C Tunis
    Public Health Agency of Canada, Centre for Immunization and Respiratory Infectious Diseases, Ottawa, ON.
  • M I Salvadori
    NACI Measles, Mumps, Rubella, Varicella Working Group Chair, London, ON.
  • V Dubey
    NACI Measles, Mumps, Rubella, Varicella Working Group Vice Chair, Toronto, ON.
  • O Baclic
    Public Health Agency of Canada, Centre for Immunization and Respiratory Infectious Diseases, Ottawa, ON.

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