Engineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery.

Journal: Polymers
Published Date: Mar 15, 2018

Abstract

Multifunctional drug carriers have great applications in biomedical field. In this study, we introduced both polydopamine (PDA) and zwitterionic polymer of poly(3-(3-methacrylamidopropyl-(dimethyl)-ammonio)propane-1-sulfonate) (PSPP) onto the surface of mesoporous silica nanoparticles (MSNs) to develop a novel nanoparticle (MSNs@PDA-PSPP), which was employed as a new kind of drug carrier for the delivery of doxorubicin (DOX). The PDA coating, as a gatekeeper, could endow the drug carrier with pH-sensitive drug release performance. The outermost PSPP layer would make the drug carrier possess protein resistance performance. The chemical structure and properties were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS) and thermogravimetric analysis (TGA). MSNs@PDA-PSPP could keep good colloidal stability within 72 h in phosphate buffered saline (PBS) and protein solutions. Meanwhile, MSNs@PDA-PSPP exhibited a high drug loading for DOX. In vitro drug release experiments suggested MSNs-DOX@PDA-PSPP exhibited pH-dependent drug release behaviors. Besides, MSNs@PDA-PSPP had no cytotoxicity to human hepatocellular carcinoma cells (HepG2 cells) even at a concentration of 125 µg/mL. More importantly, cellular uptake and in vitro anticancer activity tests suggested that MSNs-DOX@PDA-PSPP could be taken up by HepG2 cells and DOX could be successfully released and delivered into the cell nuclei. Taken together, MSNs@PDA-PSPP have great potential in the biomedical field.

Authors

  • Feng Ji
    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. jifeng@tju.edu.cn.
  • Hong Sun
    Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
  • Zhihui Qin
    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. zhihuiqin@tju.edu.cn.
  • Ershuai Zhang
    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. eszhang@tju.edu.cn.
  • Jing Cui
    School of Materials and Chemical Engineering, Zhengzhou University of Light Industry, No. 136, Science Avenue, Zhengzhou, 450001, China.
  • Jinmei Wang
    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. wangjinmei067@163.com.
  • Shuofeng Li
    Department of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063000, China. 15011337200@163.com.
  • Fanglian Yao
    School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. yaofanglian@tju.edu.cn.

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