The effects of short-term use of granulocyte colony-stimulating factor on bone metabolism in child cancer patients.

Journal: Northern clinics of Istanbul
Published Date: Dec 3, 2018

Abstract

OBJECTIVE: The granulocyte colony-stimulating factor (G-CSF) is the most commonly used hematopoietic growth factor recombinant DNA technology. It affects bone metabolism by modulating both osteoclast and osteoblast functions. The aim of the present study was to investigate the effects of short-term use of G-CSF on bone metabolism in children with leukemia and solid tumors.

Authors

  • Ayse Bozkurt Turhan
    Division of Pediatric Hematology-Oncology, Department of Pediatrics, Goztepe Training and Research Hospital of Istanbul Medeniyet University, Istanbul, Turkey.
  • Cigdem Binay
    Division of Pediatric Endocrinology, Department of Pediatrics, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Ozcan Bor
    Division of Pediatric Hematology-Oncology, Department of Pediatrics, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.
  • Enver Simsek
    Division of Pediatric Endocrinology, Department of Pediatrics, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey.

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