Anti-microbial and anti-mycotoxigenic activities of endophytic isolated from (L.) G. Don.: molecular characterisation and bioactive compound isolation.

Journal: Mycology
Published Date: Nov 5, 2018

Abstract

The present study investigated the anti-microbial and anti-mycotoxigenic activities of the ethyl acetate extract (EA) and a bioactive compound obtained from an endophytic fungus isolated from leaves. was identified using PCR-based 5.8S rDNA sequencing. The EA and bioactive compound, -Coumaric acid (PC), showed concentration-dependent broad-spectrum anti-microbial activity against the tested bacteria, yeast, and fungi with MICs ranging from 7.8 to 250 µg/mL. The production of aflatoxin B (AFB) from and fumonisin B (FB) from was completely inhibited by EA and PC at 400 µg/mL. The synthesis of the membrane-bound ergosterol from and was strongly inhibited by PC at 200 µg/mL. The EA and PC were found to show significant anti-microbial and anti-mycotoxigenic activities, hence, they could be explored as protective agents for preventing microbial deterioration and mycotoxins accumulation in food and feedstuffs during pre- and post-harvest and storage.

Authors

  • T N Sudharshana
    Department of Microbiology and Biotechnology, Bangalore University, Bengaluru, India.
  • H N Venkatesh
    Department of Microbiology and Biotechnology, Bangalore University, Bengaluru, India.
  • Borah Nayana
    Department of Microbiology and Biotechnology, Bangalore University, Bengaluru, India.
  • K Manjunath
    Department of Microbiology and Biotechnology, Bangalore University, Bengaluru, India.
  • D C Mohana
    Department of Microbiology and Biotechnology, Bangalore University, Bengaluru, India.

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