Tacrolimus Suppositories in Therapy-Resistant Ulcerative Proctitis.

Journal: Inflammatory intestinal diseases
Published Date: Nov 9, 2018

Abstract

BACKGROUND: Ulcerative proctitis may often be managed with topical salicylates or steroids alone, but in some patients, symptoms are persistent and severe. We analyzed the efficacy of tacrolimus suppositories in patients who had proven refractory to combined topical and systemic treatment.

Authors

  • Simon U Jaeger
    Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
  • Thomas Klag
    Department of Internal Medicine I, University Hospital, University of Tübingen, Tübingen, Germany.
  • Katharina Hoeger
    Department of Gastroenterology and Hepatology, Robert Bosch Krankenhaus, Stuttgart, Germany.
  • Siegfried Klumpp
    Pharmacy, Robert Bosch Krankenhaus, Stuttgart, Germany.
  • Markus Escher
    Gastroenterologie Leonberg, Leonberg, Germany.
  • Nisar Malek
    Department of Internal Medicine I, University Hospital, University of Tübingen, Tübingen, Germany.
  • Eduard Stange
    Department of Internal Medicine I, University Hospital, University of Tübingen, Tübingen, Germany.
  • Jan Wehkamp
    Department of Internal Medicine I, University Hospital, University of Tübingen, Tübingen, Germany.

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