Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort.

Journal: JNCI cancer spectrum
Published Date: Feb 21, 2019

Abstract

BACKGROUND: Circulating cell-free DNA (cfDNA) is a proposed latent biomarker for several cancers, including liver cancer. Deoxyribonucleases (DNases) facilitate the timely and efficient degradation of cfDNA, leading us to hypothesize that DNase I and/or II might be a more sensitive early biomarker than cfDNA. To test this hypothesis, a study was conducted in a large, prospective cohort.

Authors

  • Rachel M Golonka
  • Beng San Yeoh
  • Jessica L Petrick
  • Stephanie J Weinstein
  • Demetrius Albanes
  • Andrew T Gewirtz
  • Katherine A McGlynn
  • Matam Vijay-Kumar
    Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.

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