Walnut phenolic extracts reduce telomere length and telomerase activity in a colon cancer stem cell model.

Journal: Nutrition research and practice
Published Date: Dec 3, 2018

Abstract

BACKGROUND/OBJECTIVES: Telomeres are located at the chromosomal ends and progressively shortened during each cell cycle. Telomerase, which is regulated by and -, maintains telomeric DNA sequences. Especially, telomerase is active in cancer and stem cells to maintain telomere length for replicative immortality. Recently we reported that walnut phenolic extract (WPE) can reduce cell viability in a colon cancer stem cell (CSC) model. We, therefore, investigated the effect of WPE on telomere maintenance in the same model.

Authors

  • Phil-Kyung Shin
    CHA University School of Medicine, 120, Haeryong-ro, Pocheon-si, Gyeonggi 13488, Korea.
  • Yoonchae Zoh
    CHA University School of Medicine, 120, Haeryong-ro, Pocheon-si, Gyeonggi 13488, Korea.
  • Jina Choi
    CHA University School of Medicine, 120, Haeryong-ro, Pocheon-si, Gyeonggi 13488, Korea.
  • Myung-Sunny Kim
    Division of Nutrition and Metabolism, Korea Food Research Institute, Jeonju, Jeonbuk 55365, Korea.
  • Yuri Kim
    Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, 03760, Korea.
  • Sang-Woon Choi
    CHA University School of Medicine, 120, Haeryong-ro, Pocheon-si, Gyeonggi 13488, Korea.

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