Platelet mitochondrial cytochrome c oxidase subunit I variants with benzene poisoning.

Journal: Journal of thoracic disease
Published Date: Dec 1, 2018

Abstract

BACKGROUND: Chronic benzene poisoning (CBP) is one of the most common chronic occupational poisoning which is associated with mitochondrial oxidative damage, and lead to increasing risk of respiratory diseases such as lung cancer. Cytochrome c oxidase subunit I (COI) is one of the key enzymes that plays an important role in oxidative damage regulation by eliminating reactive oxygen species (ROS). This study investigated the relationship between COI gene variants and the risk of CBP.

Authors

  • Dianpeng Wang
    Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen 518020, China.
  • Xiangli Yang
    Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen 518020, China.
  • Yanfang Zhang
    Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen 518020, China.
  • Dafeng Lin
    Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen 518020, China.
  • Paimao Li
    Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen 518020, China.
  • Zhiming Zhang
    Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen 518020, China.
  • Xianqing Huang
    Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen 518020, China.
  • Dayong Gu
    Shenzhen International Travel Health Care Center and Shenzhen Academy of Inspection and Quarantine, Shenzhen 518033, China.
  • Jacky Fong-Chuen Loo
    Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China.

Keywords

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