Different Expressions of Specific Transcription Factors of Th1 () and Th2 cells () by Peripheral Blood Mononuclear Cells From Patients With Multiple Sclerosis.

Journal: Basic and clinical neuroscience
Published Date: Nov 1, 2018

Abstract

INTRODUCTION: Multiple Sclerosis (MS) is an inflammatory disorder caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. The Th1 and Th2 cell differentiation are regulated by specific transcription factors, especially and , respectively. This investigation aimed to measure the and expression by Peripheral Blood Mononuclear Cells (PBMCs) obtained from MS patients after specific and non-specific in vitro stimulation.

Authors

  • Zahra Etesam
    Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
  • Maryam Nemati
    Department of Immunology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Mohammad-Amin Ebrahimizadeh
    Department of Immunology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Hossain-Ali Ebrahimi
    Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
  • Hossain Hajghani
    Department of Immunology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Tahereh Khalili
    Department of Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Abdollah Jafarzadeh
    Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

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