Two-dimensional TiO nanoflakes enable rapid SALDI-TOF-MS detection of toxic small molecules (dyes and their metabolites) in complex environments.

Journal: Talanta
Published Date: Nov 30, 2018

Abstract

High surface area (136 m g) nanoporous two-dimensional TiO nanoflakes are applied as an adsorbent and meanwhile a matrix for toxic small molecule analysis using positive-ion surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). The TiO nanoflakes enable one-step enrichment and analysis, greatly simplifying the analysis technique. Due to the high enrichment efficiency and low background noise, small molecule organic contaminants at ppt or even sub-ppt concentrations such as malachite green (10 pg/mL), leucomalachite green (10 pg/mL), cetyltrimethylammonium bromide (0.001 pg/mL), rhodamine B (0.001 pg/mL), and crystal violet (0.1 pg/mL) were detected. In addition, malachite green and its metabolite leucomalachite green at ng/mL concentrations were successfully detected from fish blood and fish extracts, and crystal violet and its homologues at ng/cm concentrations were detected from inks on thermal receipt papers obtained from local supermarket.

Authors

  • Chan Gao
    State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
  • Deshuai Zhen
    State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China; College of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun, Guizhou 558000, China.
  • Ni He
    Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, People's Republic of China.
  • Zhengbin An
    State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
  • Qiulan Zhou
    State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
  • Chenyi Li
    State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
  • Craig A Grimes
    Flux Photon Corporation,5950 Shiloh Road East, Alpharetta, GA 30005 United States.
  • Qingyun Cai
    State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. Electronic address: qycai0001@hnu.edu.cn.

Keywords

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