A GC-MS method for the determination of furanylfentanyl and ocfentanil in whole blood with full validation.

Journal: Forensic toxicology
Published Date: Oct 22, 2018

Abstract

PURPOSE: Fentanyl analogues are popular in recent years among drug addicts and have been related to many overdoses and deaths worldwide. Furanylfentanyl, ocfentanil, acetylfentanyl and butyrfentanyl are among the most common of these drugs. Methods for the determination of furanylfentanyl and ocfentanil by gas chromatography-mass spectrometry (GC-MS) in biological samples do not exist, and therefore, their development would be extremely useful for routine toxicological analysis.

Authors

  • Nektaria Misailidi
    1Department of Forensic Medicine and Toxicology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 115 27 Athens, Greece.
  • Sotiris Athanaselis
    1Department of Forensic Medicine and Toxicology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 115 27 Athens, Greece.
  • Panagiota Nikolaou
    1Department of Forensic Medicine and Toxicology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 115 27 Athens, Greece.
  • Maria Katselou
    1Department of Forensic Medicine and Toxicology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 115 27 Athens, Greece.
  • Yannis Dotsikas
    2Laboratory of Pharmaceutical Analysis, Department of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece.
  • Chara Spiliopoulou
    1Department of Forensic Medicine and Toxicology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 115 27 Athens, Greece.
  • Ioannis Papoutsis
    1Department of Forensic Medicine and Toxicology, Faculty of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 115 27 Athens, Greece.

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