Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of MrgprA3/TRPA1-mediated pathway.

Journal: Journal of ginseng research
Published Date: May 18, 2017

Abstract

BACKGROUND: It was previously found that Korean Red Ginseng water extract (KRGE) inhibits the histamine-induced itch signaling pathway in peripheral sensory neurons. Thus, in the present study, we investigated whether KRGE inhibited another distinctive itch pathway induced by chloroquine (CQ); a representative histamine-independent pathway mediated by MrgprA3 and TRPA1.

Authors

  • Wook-Joo Lee
    College of Pharmacy, Gachon University, Incheon, Republic of Korea.
  • Young-Sik Kim
    Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
  • Won-Sik Shim
    College of Pharmacy, Gachon University, Incheon, Republic of Korea.

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