Purification of influenza virus-like particles using sulfated cellulose membrane adsorbers.

Journal: Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)
Published Date: Dec 16, 2017

Abstract

BACKGROUND: Vaccines based on virus-like particles (VLPs) are an alternative to inactivated viral vaccines that combine good safety profiles with strong immunogenicity. In order to be economically competitive, efficient manufacturing is required, in particular downstream processing, which often accounts for major production costs. This study describes the optimization and establishment of a chromatography capturing technique using sulfated cellulose membrane adsorbers (SCMA) for purification of influenza VLPs.

Authors

  • Sofia B Carvalho
    iBET, Instituto de Biologia Experimental e Tecnológica Oeiras Portugal.
  • A Raquel Fortuna
    Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg Germany.
  • Michael W Wolff
    Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg Germany.
  • Cristina Peixoto
    iBET, Instituto de Biologia Experimental e Tecnológica Oeiras Portugal.
  • Paula M Alves
    iBET, Instituto de Biologia Experimental e Tecnológica Oeiras Portugal.
  • Udo Reichl
    Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg Germany.
  • Manuel Jt Carrondo
    iBET, Instituto de Biologia Experimental e Tecnológica Oeiras Portugal.

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