Comparison of Albendazole Cytotoxicity in Terms of Metabolite Formation in Four Model Systems.

Journal: Journal of veterinary research
Published Date: Sep 19, 2017

Abstract

INTRODUCTION: Albendazole is used to treat endoparasitic diseases in animals and humans. After oral administration, it is quickly oxidised into its pharmacologically active metabolite albendazole sulfoxide and then to sulfone. However, it is not clear which compound is responsible for toxic effects towards mammalian cells.

Authors

  • Lidia Radko
    Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland.
  • Maria Minta
    Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland.
  • Piotr Jedziniak
    Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland.
  • Sylwia Stypuła-Tręba
    Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland.

Keywords

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