Addition of Exogenous γ-Glutamyl Hydrolase Eliminates the Need for Lengthy Incubation of Whole-Blood Lysate for Quantitation of Folate Vitamers by High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

Journal: Current developments in nutrition
Published Date: Nov 22, 2017

Abstract

BACKGROUND: Measurement of folate monoglutamates by HPLC-tandem mass spectrometry (HPLC-MS/MS) in whole-blood lysate (WBL) requires lengthy incubation before analysis, risking degradation of labile folate vitamers.

Authors

  • Rosemary A Stamm
    Oak Ridge Institute for Science and Education, Oak Ridge, TN.
  • Zia Fazili
    Division of Laboratory Sciences, National Center for Environmental Health, CDC, Atlanta, GA.
  • Christine M Pfeiffer
    Division of Laboratory Sciences, National Center for Environmental Health, CDC, Atlanta, GA.

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