Relations of established aging biomarkers (IL-6, D-dimer, s-VCAM) to glomerular filtration rate and mortality in community-dwelling elderly adults.

Journal: Clinical kidney journal
Published Date: Sep 27, 2017

Abstract

BACKGROUND: Biomarkers improving risk prediction for elderly populations with chronic kidney disease (CKD), an independent predictor of mortality, could be particularly useful. We previously observed that interleukin-6 (IL-6), D-dimer and soluble vascular adhesion molecule (s-VCAM) were independent biomarkers of mortality in elderly individuals. Therefore, we investigated whether these established biomarkers were independently associated with both estimated glomerular filtration rate (eGFR) and mortality.

Authors

  • John W Stanifer
    Department of Medicine, Division of Nephrology, Duke University School of Medicine, Durham, NC, USA.
  • Lawrence Landerman
    Duke University Older Americans Independence Center; Duke University School of Medicine; Duke University; Durham, NC, USA.
  • Carl F Pieper
    Duke University Older Americans Independence Center; Duke University School of Medicine; Duke University; Durham, NC, USA.
  • Kim M Huffman
    Department of Medicine, Division of Rheumatology, Duke University School of Medicine, Durham, NC, USA.
  • William E Kraus
    Duke Molecular Physiology Institute, Duke University School of Medicine, Duke University, Durham, NC, USA.

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