Synchronous Medical Image Augmentation framework for deep learning-based image segmentation.

Journal: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Published Date:

Abstract

Various deep learning (DL) models are widely applied in medical image analysis, and their performance depends on the scale and diversity of available training data. However, medical images often suffer from difficulty in data acquisition, imbalance in sample categories, and high cost of labeling. In addition, most image augmentation approaches mainly focus on image synthesis only for classification tasks, and rarely consider the synthetic image-label pairs for image segmentation tasks. In this paper, we focus on the medical image augmentation for DL-based image segmentation and the synchronization between augmented image samples and their labels. We design a Synchronous Medical Image Augmentation (SMIA) framework, which includes two modules based on stochastic transformation and synthesis, and provides diverse and annotated training sets for DL models. In the transform-based SMIA module, for each medical image sample and its tissue segments, a subset of SMIA factors with a random number of factors and stochastic parameter values are selected to simultaneously generate augmented samples and the paired tissue segments. In the synthesis-based SMIA module, we randomly replace the original tissues with the augmented tissues using an equivalent replacement method to synthesize new medical images, which can well maintain the original medical implications. DL-based image segmentation experiments on bone marrow smear and dermoscopic images demonstrate that the proposed SMIA framework can generate category-balanced and diverse training data, and have a positive impact on the performance of the models.

Authors

  • Jianguo Chen
    College of Veterinary Medicine, Wuhan, China.
  • Nan Yang
    Department of Infectious Disease, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: Shmily.1989.2008@stu.xjtu.edu.cn.
  • Yuhui Pan
    Donnelly Centre for Cellular and Biomolecular Research, Department of Molecular Genetics and Department of Computer Science at University of Toronto, Toronto, ON M5S 3E2, Canada.
  • Hailing Liu
    Department of Radiology, Binhai County People's Hospital, Yancheng 224500, Jiangsu, China.
  • Zhaolei Zhang
    Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.