[Influence of Fe O nanoparticles on the rhological properties of simulated asthma airway mucus].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Published Date: Apr 25, 2017

Abstract

The properties of mucus in a person with asthma can alter with disease process so that it may lead to the airway embolism. Fe O nanoparticles can be used for drug delivery. Up till now, however, little is known about how the Fe O nanoparticles influence the properties of airway mucus. In this study, Fe O nanoparticles were dispersed with ultrasound, and the morphological properties were measured with scanning electron microscope, atomic force microscope and nanometer laser particle size and zeta potential analyzer. Then the dispersed Fe O nanoparticles were added to the simulated asthma airway mucus with different final concentration (0.03, 0.3, and 0.4 mg/mL). The measurements of flow curve, yield stress, large amplitude oscillatory shear (LAOS) and shock scanning were carried out with a rotational rheometer. Experimental results showed that the Fe O nanoparticles reduced the zero shear viscosity of simulated asthma airway mucus. With increase of shear rate, the wind speed of mucus was reduced. The yield stress of simulated asthma airway mucus was 19.0 Pa, but the yield stresses of experimental group (0.03, 0.3 and 0.4 mg/mL) were 17.0, 0.99, and 0.7 Pa, respectively. The results showed that the viscoelastic modulus of asthma airway mucus treated with Fe O nanoparticles were changed obviously as measured with large amplitude scanning and frequency scanning. By adopting the method of optical phase microscopy, we found that different structures of simulated airway mucus were absorbed. The results showed Fe O nanoparticles distroyed mucus structure. The experimental results proved that Fe O nanoparticles could change the rheological characteristics of simulated asthma airway mucus. This experimental result would lay a foundation for the further development of airway mucus sticky agent based on the function of Fe O nanoparticles.

Authors

  • Jiali Wang
    Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, P.R.China.
  • Mingzhi Luo
    Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, P.R.China.luomingzhi@cczu.edu.cn.
  • Zhiwei Liu
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province, 430070 China.
  • Yang Jin
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing University, Chongqing 400030, P.R.China.
  • Shuai Liang
    School of petrochemical engineering, Changzhou University, Changzhou, Jiangsu 213164, P.R.China.
  • Lei Liu
    Department of Science and Technology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Xingmao Jiang
    School of petrochemical engineering, Changzhou University, Changzhou, Jiangsu 213164, P.R.China.
  • Linhong Deng
    Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, P.R.China;Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing University, Chongqing 400030, P.R.China.

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