Lipid nanocapsules formulation and cellular activities evaluation of a promising anticancer agent: EAPB0503.

Journal: International journal of pharmaceutical investigation
Published Date: Jan 1, 2017

Abstract

OBJECTIVE: EAPB0503, lead compound of imiqualines, presented high antitumor activities but also a very low water solubility which was critical for further preclinical studies. To apply to EAPB0503, a robust and safe lipid formulation already used for poor soluble anticancer agents for injectable administration at a concentration higher than 1 mg/mL.

Authors

  • Adrien Chouchou
    CNRS, ENSCM, IBMM, University of Montpellier, Montpellier, France.
  • Anne Aubert-Pouëssel
    UMR 5253, CNRS, ENSCM, University of Montpellier, Institut Charles Gerhardt Montpellier, Montpellier, France.
  • Christophe Dorandeu
    UMR 5253, CNRS, ENSCM, University of Montpellier, Institut Charles Gerhardt Montpellier, Montpellier, France.
  • Zahraa Zghaib
    CNRS, ENSCM, IBMM, University of Montpellier, Montpellier, France.
  • Pierre Cuq
    CNRS, ENSCM, IBMM, University of Montpellier, Montpellier, France.
  • Jean-Marie Devoisselle
    UMR 5253, CNRS, ENSCM, University of Montpellier, Institut Charles Gerhardt Montpellier, Montpellier, France.
  • Pierre-Antoine Bonnet
    CNRS, ENSCM, IBMM, University of Montpellier, Montpellier, France.
  • Sylvie Bégu
    UMR 5253, CNRS, ENSCM, University of Montpellier, Institut Charles Gerhardt Montpellier, Montpellier, France.
  • Carine Deleuze-Masquefa
    CNRS, ENSCM, IBMM, University of Montpellier, Montpellier, France.

Keywords

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