Overproduction of efflux pumps caused reduced susceptibility to carbapenem under consecutive imipenem-selected stress in .

Journal: Infection and drug resistance
Published Date: Mar 29, 2018

Abstract

PURPOSE: is an important pathogen in the nosocomial infections worldwide. Combining with carbapenemases, efflux pumps and outer membrane proteins (OMPs) have been thought to affect the development of carbapenem resistance in . This study aimed to investigate the contributions of different efflux pumps and OMPs in developing carbapenem resistance in a clinical isolate of and reveal the possible mechanism of overproduction of main efflux pumps.

Authors

  • Yanpeng Zhang
    Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
  • Zhuocheng Li
    Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Xiaolong He
    Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
  • Fanglin Ding
    Laboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
  • Weiqing Wu
    Laboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
  • Yong Luo
    Laboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
  • Bing Fan
    Laboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
  • Hong Cao
    Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.

Keywords

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