Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction.

Journal: Frontiers in physiology
Published Date: Jan 15, 2025

Abstract

INTRODUCTION: Interleukin-10 (IL-10) is a potent immunomodulatory cytokine widely explored as a therapeutic agent for diseases, including myocardial infarction (MI). High-dose IL-10 treatment may not achieve expected outcomes, raising the question of whether IL-10 has dose-dependency, or even uncharted side-effects from overdosing. We hypothesized that IL-10 has dose-dependent effects on macrophage (Mφ) phenotypic transition and cardiac remodeling after MI.

Authors

  • Jing J Zhang
    Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
  • Rodrigue Rizk
    Department of Computer Science, University of South Dakota, Vermillion, SD, United States.
  • Xiaoping Li
    Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
  • Brandon G Lee
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States.
  • Mason L Matthies
    Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
  • Kennedy A Bietz
    Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
  • Kang Kim
    Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States.
  • Johnny Huard
    The Linda & Mitch Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO, United States.
  • Yadong Wang
    The Biofoundry, Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States.
  • William C W Chen
    Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.

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