Effect of the (Mill.) N.E. Brown essential oil and its main constituents, citral and limonene, on the tracheal smooth muscle of rats.

Journal: Biotechnology reports (Amsterdam, Netherlands)
Published Date: Dec 6, 2017

Abstract

The (Mill.) N.E. Brown (Verbenaceae) species, has effects sedative, analgesic and spasmolytic properties. This study had as its main objective to evaluate the essential oil of (EOLa) effect and that of its main constituents, citral and limonene, over tracheal smooth muscle from Wistar rats. EOLa, citral and limonene promoted relaxation of tracheal smooth muscle in contractions induced by potassium (60 mM K), presenting an EC of 148 ± 7 μg/mL for the EOLa, 136 ± 7 μg/mL for citral and 581 ± 7 μg/mL for limonene. In contractions induced by Acetylcholine (Ach; 10 μM) the EC for the EOLa and citral were of 731 ± 5 μg/mL and 795 ± 9 μg/mL, respectively. In preparations pre-incubated with 1000 μg/mL of the EOLa and citral, both agents were found to block the influx of BaCl by VOCCs. This study demonstrated that the EOLa and its main component citral present antispasmodic effect over tracheal smooth muscle of rats.

Authors

  • Poliana M M Carvalho
    Physiopharmacology of Excitability Cell Laboratory, Department of Chemical Biology Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.
  • Cícero A F Macêdo
    Physiopharmacology of Excitability Cell Laboratory, Department of Chemical Biology Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.
  • Tiago F Ribeiro
    Physiopharmacology of Excitability Cell Laboratory, Department of Chemical Biology Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.
  • Andressa A Silva
    Physiopharmacology of Excitability Cell Laboratory, Department of Chemical Biology Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.
  • Renata E R Da Silva
    Physiopharmacology of Excitability Cell Laboratory, Department of Chemical Biology Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.
  • Luís P de Morais
    Physiopharmacology of Excitability Cell Laboratory, Department of Chemical Biology Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.
  • Marta R Kerntopf
    Pharmacology of Natural Products Laboratory, Regional University of Cariri-Campus of Pimenta, 63105-010, Crato, CE, Brazil.
  • Irwin R A Menezes
    1 Universidade Regional do Cariri, Crato, Brasil.
  • Roseli Barbosa
    Physiopharmacology of Excitability Cell Laboratory, Department of Chemical Biology Regional University of Cariri, Campus of Pimenta, 63105-010, Crato, CE, Brazil.

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