Antibacterial Activity of : Identification of Hispidulin and Dehydromelitensin-8-(4ꞌ-Hydroxy-Methacrylate).

Journal: Iranian journal of pharmaceutical research : IJPR
Published Date: Jan 1, 2017

Abstract

Hexane, ethyl acetate and methanol extracts of leaves were investigated for their antibacterial activities against , , , , and . Hexane and ethyl acetate extracts were toxic to Gram-positive bacteria with inhibition zone diameters ranging between 12 and 30 mm. Two products, hispidulin , and dehydromelitensin-8-(4ꞌ-hydroxy-methacrylate) 2 were isolated from the ethyl acetate extract of leaves and identified by 2D-NMR for the first time from this species. Ethyl acetate extractꞌs total flavonoid content was the highest, as 78.73 mg quercetin equivalents (QE)/g. The methanol extract showed the highest total phenolic content as 243.43 mg gallic acid equivalents (GAE)/g and gave the most important 2,2-diphenyl-1-picrylhydrazyl (DPPH)scavenging activity (EC = 86 µg/mL).

Authors

  • Fatma Njeh
    Laboratory of Organic Chemistry LR17ES08, Natural Substances Chemistry Team, Faculty of Sciences, 3000 Sfax, University of Sfax, Tunisia.
  • Dhekra Mhalla
    Laboratory of Biopesticides, Center of Biotechnology, 3018 Sfax, University of Sfax, Tunisia.
  • Ibtissem Ben Hammouda
    Laboratory of Organic Chemistry LR17ES08, Natural Substances Chemistry Team, Faculty of Sciences, 3000 Sfax, University of Sfax, Tunisia.
  • Mohamed Trigui
    Laboratory of Biopesticides, Center of Biotechnology of Sfax, University of Sfax, P.O. Box 1177, 3018 Sfax, Tunisia.
  • Raoudha Mezghani-Jarraya
    Laboratory of Organic Chemistry LR17ES08, Natural Substances Chemistry Team, Faculty of Sciences, 3000 Sfax, University of Sfax, Tunisia.

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