NDUFA11 may be the disulfidptosis-related biomarker of ischemic stroke based on integrated bioinformatics, clinical samples, and experimental analyses.

Journal: Frontiers in neuroscience
Published Date: Jan 14, 2025

Abstract

BACKGROUND: Programmed cell death plays an important role in neuronal injury and death after ischemic stroke (IS), leading to cellular glucose deficiency. Glucose deficiency can cause abnormal accumulation of cytotoxic disulfides, resulting in disulfidptosis. Ferroptosis, apoptosis, necroptosis, and autophagy inhibitors cannot inhibit this novel programmed cell death mechanism. Nevertheless, the potential mechanisms of disulfidptosis in IS remain unclear.

Authors

  • Sijun Li
    Department of Geriatric Rehabilitation, Jiangbin Hospital, Nanning, China.
  • Ningyuan Chen
    Department of Pathophysiology, Guangxi Medical University, Nanning, China.
  • Junrui He
    Department of Geriatric Rehabilitation, Jiangbin Hospital, Nanning, China.
  • Xibao Luo
    Department of Geriatric Rehabilitation, Jiangbin Hospital, Nanning, China.
  • Wei Lin
    Department of Geriatric Rehabilitation, Jiangbin Hospital, Nanning, China.

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