ATP-binding cassette transporter A1: A promising therapy target for prostate cancer.

Journal: Molecular and clinical oncology
Published Date: Nov 15, 2017

Abstract

ATP-binding cassette transporter A1 (ABCA1) has been found to mediate the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A-I (apoA-I), and is essential for the synthesis of high-density lipoprotein. Mutations of the ABCA1 gene may induce Tangier disease and familial hypoalphalipoproteinemia; they may also lead to loss of cellular cholesterol homeostasis in prostate cancer, and increased intracellular cholesterol levels are frequently found in prostate cancer cells. Recent studies have demonstrated that ABCA1 may exert anticancer effects through cellular cholesterol efflux, which has been attracting increasing attention in association with prostate cancer. The aim of the present review was to focus on the current views on prostate cancer progression and the various functions of ABCA1, in order to provide new therapeutic targets for prostate cancer.

Authors

  • Ting Xiong
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Gang Xu
    University Hospitals of Leicester NHS Trust; UK.
  • Xue-Long Huang
    Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Kai-Qiang Lu
    Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Wei-Quan Xie
    Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Kai Yin
    Department of Diagnostics Teaching and Research, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Jian Tu
    Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China.

Keywords

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