The -2 as a Target Gene of Curcumin to Protect Hepatocytes Against the Arsenic-induced Carcinoma in Mice.

Journal: Iranian journal of pathology
Published Date: Apr 1, 2017

Abstract

BACKGROUND & OBJECTIVE: The gene is an important on co protein overexpressed in many types of cancers. The current study hypothesized that curcumin downregulates and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFκB, which could be useful to treat overexpressed-HER-2 hepatocellular carcinoma (HCC).

Authors

  • Mahdi Ahadi
    Dept. of Biology, Faculty of Biological Sciences, Parand Branch, Islamic Azad University, Parand, Iran.
  • Vahid Naseh
    Dept. of Biology, Faculty of Biological Sciences, Parand Branch, Islamic Azad University, Parand, Iran.
  • Masoud Salehipour
    Dept. of Biology, Faculty of Biological Sciences, Parand Branch, Islamic Azad University, Parand, Iran.

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