Endothelial markers in high altitude induced systemic hypertension (HASH) at moderate high altitude.

Journal: Medical journal, Armed Forces India
Published Date: Nov 15, 2017

Abstract

BACKGROUND: Chronic intermittent hypoxia is known to induce systemic arterial hypertension whereas chronic hypoxia causes pulmonary arterial hypertension. High altitude (HA) induced systemic hypertension (HASH) in previously normotensive lowlanders following acclimatisation and prolonged stay at moderate HA is a commonly encountered medical problem. HASH has been attributed to increased sympathetic discharge. Endothelial dysfunction (ED) is implicated in hypertension in the plains hence this study was conducted in HA. This is relevant especially because of the established role of ED in the aetiopathogenesis of HA illnesses. Since hypoxia may induce ED, we aimed at studying the association of endothelial dysfunction with HASH in temporary residents at HA.

Authors

  • Uday Yanamandra
    Classified Specialist (Med) & Hematologist, Army Hospital (Research & Referral), Delhi Cantt 110010, India.
  • S P Singh
    Indian Council of Agricultural Research (ICAR), Central Institute for Research on Goats, Makhdoom, Farah, Mathura, Uttar Pradesh (U.P.), India.
  • Sushma Yanamandra
    Medical Officer, Max Hospital, Mohali, Punjab 160012, India.
  • Deepak Mulajkar
    Classified Specialist (Med) & Oncologist, Command Hospital (Southern Command), Pune, 411040, India.
  • R S Grewal
    MG (Med) Eastern Command Fort William, Kolkata, India.
  • Shashibala Singh
    DS & Director General, Life Sciences (LS), DRDO, Ministry of Defence, DRDO Bhavan, New Delhi 110011, India.
  • M Z Ashraf
    Former Scientist E &, Division Head, Genomics Division, DIPAS, DRDO, Timarpur, Delhi 110054, India.
  • Prasanna Reddy
    Scientist F, DIPAS, DRDO, Timarpur, Delhi 110054, India.
  • Velu Nair
    Former Director General Medical Services (Army), Integrated Headquarters, Ministry of Defence, New Delhi 110001, India.

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