Biological activities of plant extracts from and : An antimalarial, antitrypanosomal and cytotoxity evaluation.

Journal: Saudi journal of biological sciences
Published Date: Jul 20, 2017

Abstract

The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Roxb. ex Hornem. aerial roots (Moraceae) and Spring (Selaginellaceae) leaves were collected from two different sites in Cameroon. cell-growth inhibition activities were assessed on methanol extract of plant materials against strain 3D7 and , as well as against HeLa human cervical carcinoma cells. Criteria for activity were an IC value < 10 μg/mL. The extract of did not significantly reduce the viability of at a concentration of 25 μg/mL but dramatically affected the trypanosome growth with an IC of 2.4 μg/mL. In contrast, at the same concentration, the extract of exhibited plasmodiacidal activity (IC value of 9.5 μg/mL) and trypanocidal (IC value of 0.9 μg/mL) activity. Both extracts presented low cytotoxic effects on HeLa cancer cell line. These results indicate that the selected medicinal plants could be further investigated for identifying compounds that may be responsible for the observed activities and that may represent new leads in parasitical drug discovery.

Authors

  • Jean Emmanuel Mbosso Teinkela
    Département des Sciences Biologiques, Faculté de Médecine et des Sciences Pharmaceutiques (FMSP), Université de Douala, BP 2701 Douala, Cameroon.
  • Xavier Siwe Noundou
    Nanomaterials and Medicinal Organic Chemistry Laboratory, Department of Chemistry, Faculty of Science, Rhodes University, PO Box 94, Grahamstown 6140, South Africa.
  • Edwige Laure Nguemfo
    Département des Sciences Biologiques, Faculté de Médecine et des Sciences Pharmaceutiques (FMSP), Université de Douala, BP 2701 Douala, Cameroon.
  • Franck Meyer
    Laboratory of Biopolymers and Supramolecular Nanomaterials, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus Plaine (CP 206/4), Boulevard du Triomphe, 1050 Brussels, Belgium.
  • Rene Wintjens
    Laboratory of Biopolymers and Supramolecular Nanomaterials, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus Plaine (CP 206/4), Boulevard du Triomphe, 1050 Brussels, Belgium.
  • Michelle Isaacs
    Rhodes University, Faculty of Science, Department of Biochemistry and Microbiology, Grahamstown, South Africa.
  • Albert Emmanuel Mpondo Mpondo
    Département de Pharmacie, Faculté de Médecine et des Sciences Pharmaceutiques (FMSP), Université de Douala, BP 2701 Douala, Cameroon.
  • Heinrich C Hoppe
    Rhodes University, Faculty of Science, Department of Biochemistry and Microbiology, Grahamstown, South Africa.
  • Rui Werner Maçedo Krause
    Nanomaterials and Medicinal Organic Chemistry Laboratory, Department of Chemistry, Faculty of Science, Rhodes University, PO Box 94, Grahamstown 6140, South Africa.
  • Anatole Guy Blaise Azebaze
    Department of Chemistry, Faculty of Science, University of Douala, P.O. Box. 24157, Douala, Cameroon.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals