Molecular genetic studies in Saudi population; identified variants from GWAS and meta-analysis in stroke.

Journal: Saudi journal of biological sciences
Published Date: Aug 24, 2017

Abstract

INTRODUCTION: Stroke is a multifactorial and heterogeneous disorder, correlates with heritability and considered as one of the major diseases. The prior reports performed the variable models such as genome-wide association studies (GWAS), replication, case-control, cross-sectional and meta-analysis studies and still, we lack diagnostic marker in the global world. There are limited studies were carried out in Saudi population, and we aim to investigate the molecular association of single nucleotide polymorphisms (SNPs) identified through GWAS and meta-analysis studies in stroke patients in the Saudi population.

Authors

  • Khalid Khalaf Alharbi
    Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
  • Imran Ali Khan
    Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
  • Mohammad Abdullah Alotaibi
    College of Medicine, Al-Imam University, Riyadh, Saudi Arabia.
  • Abdullah Saud Aloyaid
    College of Medicine, Al-Imam University, Riyadh, Saudi Arabia.
  • Haifa Abdulaziz Al-Basheer
    Department of Pharmacy, PSMMC, Riyadh, Saudi Arabia.
  • Naelah Abdullah Alghamdi
    Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
  • Raid Saleem Al-Baradie
    College of Applied Medical Sciences, Majmaah University, Al Majmaah, Saudi Arabia.
  • A M Al-Sulaiman
    Department of Medical and Molecular Virology, PSMMC, Riyadh, Saudi Arabia.

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