Ascertainment of pharmacological activities of Hook and Roxb used in Bangladesh: An in vitro study.
Journal:
Journal of traditional and complementary medicine
Published Date:
Apr 26, 2017
Abstract
The present study was cherished to investigate in vitro thrombolytic, membrane stabilizing and antibacterial activities of and . Different types methanolic extracts of these two medicinal plants were tested for determining membrane stabilizing activity at a hypotonic solution and heat induce condition by comparing with reference standard acetyl salicylic acid (0.10 mg/mL), where thrombolytic activity assessment was done by employing Streptokinase as standard drug. Finally, antibacterial activity was performed against as a Gram-positive (+ve) and , and as Gram negative (-ve) bacteria by using disc diffusion method. In case of membrane stabilizing studies, crude methanolic extracts of at 10 mg/ml concentration, more importantly, showed 45.80% & 23.52% whereas 10 mg/ml concentration of more significantly (p < 0.01) produced 38.40% and 27.04% inhibition of hemolysis for both experimental conditions. Dose-dependently increased activity was found in the thrombolytic study where 10 mg/ml concentration of both and more significantly (p < 0.01) showed 41.91% and 32.76% lysis of clot respectively by in vitro clot lysis assay method. Crude methanolic extracts of did not show any suitable antibacterial property against the test bacteria. However, the gram positive (+ve) bacteria also seemed resistant against extract but this crude methanolic extracts was found to generate moderate antibacterial action against gram-negative (-ve) bacteria. The obtained results confirmed the presence of thrombolytic, membrane stabilizing activity for both plant extract along with moderate antibacterial activity for .
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