CA19-9-related macrophage polarization drives poor prognosis in HCC after immune checkpoint inhibitor treatment.

Journal: Frontiers in oncology
Published Date: Jan 10, 2025

Abstract

BACKGROUND: Elevated levels of carbohydrate antigen 19-9 (CA19-9) levels are known to worsen outcomes in various tumors by influencing immune responses. However, the role of CA19-9 in immunotherapy for hepatocellular carcinoma (HCC) remains poorly understood.

Authors

  • Tingting Du
    Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Jialin Zou
    Department of Anorectal Surgery, Shenzhen Longgang Central Hospital, Shenzhen, China.
  • Yunying Yang
    Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Honghui Xie
    Department of Gynecology, Lingshan County People's Hospital, Qinzhou, China.
  • Hui Pang
    Management Evaluation Section, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Wenquan Zhuang
    Department of Interventional Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Shutong Wang
    Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
  • Guangyan Wei
    Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

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