Amphotericin B tissue penetration and pharmacokinetics in healthy and -infected rats: insights from microdialysis and population modeling.

Journal: Frontiers in pharmacology
Published Date: Jan 10, 2025

Abstract

INTRODUCTION: This study evaluated the relationship between total plasma and free kidney concentrations of amphotericin B (AmB) in healthy and -infected Wistar rats using microdialysis and has the potential to significantly impact future research in this field and promote the development of antifungal drugs. The findings of this study, which show that plasma levels are a good predictor for AmB kidney concentrations and can be used to optimize its dosing regimen, underscore the importance of this research.

Authors

  • Valdeene Vieira Santos
    Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Laiz Campos Pereira
    Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Jackeline Marley Santos de Araújo
    Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Matheus Antônio da Hora Borges
    Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Carolina Magalhães Brandão
    Laboratory of Pharmacokinetics and Pharmacometrics, Faculty of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Luisa Oliveira Santos
    Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Cristiane Flora Villarreal
    Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador, Brazil.
  • Francine Johansson Azeredo
    Center for Pharmacometrics and System Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, United States.

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