The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats.

Journal: Integrative medicine research
Published Date: Aug 1, 2017

Abstract

BACKGROUND: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications.

Authors

  • Manodeep Chakraborty
    Pharmacology Department, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India.
  • Mohammed Gulzar Ahmed
    Pharmaceutics Department, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India.
  • Ananya Bhattacharjee
    Pharmacology Department, Srinivas College of Pharmacy, Mangalore 574143, India.

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