Anti-Lipase Potential of the Organic and Aqueous Extracts of Ten Traditional Edible and Medicinal Plants in Palestine; a Comparison Study with Orlistat.

Journal: Medicines (Basel, Switzerland)
Published Date: Dec 8, 2017

Abstract

Herbs have played a fundamental and essential role in the humans life since ancient times, especially those which are used as food and/or folk medicinedue to both their nutritive and curative properties.This study aimed to investigate new antilipase agents from tentraditional Palestinian edible and medicinal plants through inhibition of the absorption of dietary lipids. The anti-lipase activity for ten plants was evaluated and compared with the reference compound Orlistat by using the porcine pancreatic lipase inhibitory test which was conducted by using a UV-visible spectrophotometer. The aqueous extracts of and had the highest antilipase effects with IC values 14.13 and 19.95 mcg/mL, respectively. Meanwhile, the organic extract of had an IC value 18.62 mcg/mL. showed the highest porcine pancreatic lipase inhibitory effects when compared with Orlistat, which has an IC value 12.38 mcg/mL. According to the obtained results, , , and can be considered a natural inhibitors of the pancreatic lipase enzyme as well as new players in obesity treatment. In fact, these plants can be freely and safely consumed in a daily diet or can be prepared as nutraceutical formulations to treat or prevent of obesity.

Authors

  • Nidal Jaradat
    Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine. nidaljaradat@najah.edu.
  • Abdel Naser Zaid
    Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine. anzaid@najah.edu.
  • Fatima Hussein
    Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine. f.huseen@najah.edu.
  • Maram Zaqzouq
    Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine. maram-zaqzouq@hotmail.com.
  • Hadeel Aljammal
    Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine. hadeeljawad133@outlook.com.
  • Ola Ayesh
    Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine. oayesh@najah.edu.

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