Development of Tolerance to Chronic Intermittent Furosemide Therapy in Pediatric Patients.

Journal: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Published Date: Jan 1, 2017

Abstract

OBJECTIVES: The purpose of this study is to describe whether tolerance develops in pediatric patients receiving chronic intermittent furosemide therapy, to characterize when it occurs and whether age-related variations exist. The effects of increasing total daily dose of furosemide and concurrent diuretics and vasopressors were assessed as secondary aims.

Authors

  • Gloria J Kim
    Department of Clinical Pharmacy (GJK, GR, AHT), Rady Children's Hospital San Diego, California, Department of Pediatrics (EC, AHT), University of California, San Diego, Clinical and Translational Research Institute (JAP), University of California, San Diego.
  • Edmund Capparelli
    Pediatrics, University of California San Diego, La Jolla, USA.
  • Gale Romanowski
    Department of Clinical Pharmacy (GJK, GR, AHT), Rady Children's Hospital San Diego, California, Department of Pediatrics (EC, AHT), University of California, San Diego, Clinical and Translational Research Institute (JAP), University of California, San Diego.
  • James A Proudfoot
    Department of Clinical Pharmacy (GJK, GR, AHT), Rady Children's Hospital San Diego, California, Department of Pediatrics (EC, AHT), University of California, San Diego, Clinical and Translational Research Institute (JAP), University of California, San Diego.
  • Adriana H Tremoulet
    Department of Clinical Pharmacy (GJK, GR, AHT), Rady Children's Hospital San Diego, California, Department of Pediatrics (EC, AHT), University of California, San Diego, Clinical and Translational Research Institute (JAP), University of California, San Diego.

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