Intravenous Infusion of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Erectile Dysfunction Following Cavernous Nerve Injury in Rats.

Journal: Sexual medicine
Published Date: Dec 21, 2017

Abstract

INTRODUCTION: Intravenous preload (delivered before cavernous nerve [CN] injury) of bone marrow-derived mesenchymal stem cells (MSCs) can prevent or decrease postoperative erectile dysfunction (J Sex Med 2015;12:1713-1721). In the present study, the potential therapeutic effects of intravenously administered MSCs on postoperative erectile dysfunction were evaluated in a rat model of CN injury.

Authors

  • Yohei Matsuda
    Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Masanori Sasaki
    Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, CT, USA. Electronic address: msasaki@sapmed.ac.jp.
  • Yuko Kataoka-Sasaki
    Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Akio Takayanagi
    Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Ko Kobayashi
    Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Shinichi Oka
    Department of Gastroenterology and Minimally Invasive Surgery, Juntendo University Hospital, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.
  • Masahito Nakazaki
    Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Naoya Masumori
    Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan.
  • Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, CT, USA.
  • Osamu Honmou
    Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan; Department of Neurology, Yale University School of Medicine, New Haven, CT, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, CT, USA.

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