Quantitative pulmonary blood flow measurement using O-HO PET with and without tissue fraction correction: a comparison study.

Journal: EJNMMI research
Published Date: Dec 22, 2017

Abstract

BACKGROUND: Physiological measures per lung parenchyma, rather than per lung volume, sometimes reflect the disease status. PET images of the lung, which are usually expressed per lung volume, could confound the interpretation of the disease status, especially in cases with a prominent heterogeneity in aeration. The aim of the present study was to develop a method for measuring pulmonary blood flow (PBF) with aeration correction using O-HO PET and to compare the results with those obtained using a conventional method. We obtained the voxel-based tissue fraction (TF) derived from density images converted from transmission images obtained using an external Cs point source. Quantitative PBF values with and without the TF were calculated using O-HO PET to examine contralateral lung tissue in 9 patients with unilateral lung cancer. The heterogeneity in PBF before and after TF correction was then evaluated and compared. As a measure of PBF heterogeneity, we used the skewness and kurtosis of the PBF distribution.

Authors

  • Keiko Matsunaga
    Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Masahiro Yanagawa
    Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Tomoyuki Otsuka
    Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Haruhiko Hirata
    Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Takashi Kijima
    Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Atsushi Kumanogoh
    Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Noriyuki Tomiyama
    Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Eku Shimosegawa
    Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Jun Hatazawa
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka Suita city, Osaka, Japan. hatazawa@tracer.med.osaka-u.ac.jp.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals